Link to GOOGLE SCHOLAR PROFILE

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REPRESENTATIVE PUBLICATIONS

*Co-first authors
#Corresponding author(s)
Shikuma Lab Members
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AT Alker, N Delherbe, T Purdy, B Moore, NJ Shikuma (2020). Genetic examination of the marine bacterium Pseudoalteromonas luteoviolacea and effects of its metamorphosis-inducing factors. Environmental Microbiology. https://doi.org/10.1111/1462-2920.15211

• ​We uncover a hidden complexity of interactions between a single bacterial species, the factors it produces and two species of animal larvae.​

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GS Cavalcanti, AT Alker, N Delherbe, KE Malter, NJ Shikuma (2020). The Influence of Bacteria on Animal Metamorphosis. Annual Review of Microbiology. 74:137-58. https://doi.org/10.1146/annurev-micro-011320-012753

• ​We review what is known and what we hope to learn about how bacteria and the factors they produce stimulate animal metamorphosis.
• Here's a link to the free full text

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Maria I. Rojas*, Giselle S. Cavalcanti*, Katelyn McNair, Sean Benler, Amanda T. Alker, Ana G. Cobián-Güemes, Melissa Giluso, Kyle Levi, Forest Rohwer, Barbara Bailey, Sinem Beyhan, Robert A. Edwards, Nicholas J. Shikuma (2020). A Distinct Contractile Injection System Gene Cluster Found in a Majority of Healthy Adult Human Microbiomes. mSystems 5:e00648-20. https://doi.org/10.1128/MSYSTEMS.00648-20

• We discovered a yet undescribed Injection System genecluster in the microbiomes of nearly all adult humans. ​
• Our paper is posted as a preprint on bioRxiv. https://doi.org/10.1101/865204​

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C Ericson*, F Eisenstein*, J Medeiros, K Malter, G Cavalcanti, RW Zeller, DK Newman, M Pilhofer# and NJ Shikuma# (2019). A Contractile Injection System Stimulates Tubeworm Metamorphosis by Translocating a Proteinaceous Effector. eLife 8:e46845. https://doi.org/10.7554/eLife.46845.

• Commentary: eLife
• News Coverage: National Public Radio | BioTechniques | Medical Xpress 

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I Rocchi*, C Ericson*, KE Malter*, S Zargar, F Eisenstein, M Pilhofer, S Beyhan# and NJ Shikuma# (2019). A Bacterial Phage Tail-like Structure Kills Eukaryotic Cells by Injecting a Nuclease Effector. Cell Reports 28(2), 295-301. https://doi.org/10.1016/j.celrep.2019.06.019. 
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NJ Shikuma*#, I Antoshechkin*, J Medeiros, M Pilhofer and DK Newman (2016) Stepwise metamorphosis of the tubeworm Hydroides elegans is mediated by a bacterial inducer and MAPK signaling. Proceedings of the National Academy of Sciences 10.1073/pnas.1603142113. 

• Commentary: Science Signaling
• News Coverage: The Economist | Popular Science | SDSU News Center

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​NJ Shikuma*, M Pilhofer*, GL Weiss, MG Hadfield#, GJ Jensen# and DK Newman# (2014) Marine tubeworm metamorphosis induced by arrays of bacterial phage tail-like structures. Science 343:529-533. 

• Commentary: Science Signaling
• News Coverage: AAAS | The Scientist 

NJ Shikuma, JCN Fong and FH Yildiz (2012) Cellular levels and binding of c-di-GMP control subcellular localization and activity of the Vibrio cholerae transcriptional regulator VpsT. PLoS Pathogens 8(5):e1002719.

PV Krasteva, JCN Fong, NJ Shikuma, S Beyhan, MVAS Navarro, FH Yildiz and H Sondermann (2010) Vibrio cholerae VpsT regulates matrix production and motility by directly sensing cyclic di-GMP. Science 327:866-868.
 
NJ Shikuma and FH Yildiz (2009) Identification and characterization of OscR, a transcriptional regulator involved in osmolarity adaptation in Vibrio cholerae. Journal of Bacteriology 191:4082-4096.

• Commentary: PV Dunlap (2009) J Bacteriol 191:4053-4055. 

NJ Shikuma*, JCN Fong*, LS Odell*, BS Perchuk, MT Laub and FH Yildiz (2009) Overexpression of VpsS, a hybrid sensor kinase, enhances biofilm formation in Vibrio cholerae. Journal of Bacteriology 191:5147-5158.