*Co-first authors #Co-corresponding authors Shikuma Lab Members
Maria I. Rojas*, Giselle S. Cavalcanti*, Katelyn McNair, Sean Benler, Amanda T. Alker, Ana G. Cobián-Güemes, Melissa Giluso, Kyle Levi, Forest Rohwer, Sinem Beyhan, Robert A. Edwards, Nicholas J. Shikuma (2019). A Distinct Contractile Injection System Found in a Majority of Adult Human Microbiomes. bioRxiv. https://doi.org/10.1101/865204
We found that human gut bacteria produce a yet undescribed injection system. These new injection systems are present in the gut microbiomes of nearly all adult humans from the United States and Europe.
CEricson*, FEisenstein*, J Medeiros, K Malter, G Cavalcanti, RW Zeller, DK Newman, MPilhofer# andNJShikuma# (2019). A Contractile Injection System Stimulates Tubeworm Metamorphosis by Translocating a Proteinaceous Effector. eLife.https://doi.org/10.7554/eLife.46845.
A collaborative work between Zeller, Newman, Pilhofer and Shikuma Labs.
Published back-to-back in eLife with a paper from Nick Waterfield's lab, Univ. of Warwick.
I Rocchi*, C Ericson*, KE Malter*, S Zargar, F Eisenstein, M Pilhofer, S Beyhan# and NJ Shikuma# (2019). A Bacterial Phage Tail-like Structure Kills Eukaryotic Cells by Injecting a Nuclease Effector. Cell Reports, https://doi.org/10.1016/j.celrep.2019.06.019.
A collaborative work between Pilhofer, Beyhan and Shikuma Labs.
NJ Shikuma, JCN Fong and FH Yildiz (2012) Cellular levels and binding of c-di-GMP control subcellular localization and activity of the Vibrio cholerae transcriptional regulator VpsT. PLoS Pathogens 8(5):e1002719.
PV Krasteva, JCN Fong, NJ Shikuma, S Beyhan, MVAS Navarro, FH Yildiz and H Sondermann (2010)Vibrio cholerae VpsT regulates matrix production and motility by directly sensing cyclic di-GMP. Science 327:866-868.
NJ Shikuma and FH Yildiz (2009) Identification and characterization of OscR, a transcriptional regulator involved in osmolarity adaptation in Vibrio cholerae. Journal of Bacteriology191:4082-4096.