*Co-first authors #Corresponding author(s) Shikuma Lab Members
NJ Shikuma (In Press). Bacteria-Stimulated Metamorphosis: An Ocean of Insights from Investigating a Transient Host-Microbe Interaction. mSystems. Invited Early Career Special Collection.
A perspective piece describing our vision for the field of bacteria-stimulated metamorphosis and beyond.
AT Alker, Bhumika Gode, Alpher Aspiras, Jeffrey Jones, Sama Michael, David Aguilar, Audrea Cain, Alec M. Candib, Julian Cizmic, Elise Clark, Alyssa C. Cozzo, Laura Figueroa, Peter Garcia, Casey Heaney, Alexandra T. Levy, Luke Macknight, Anna McCarthy, John P. McNamara, Kelvin Nguyen, Kendall N. Rollin, Gabriella Y. Salcedo, Julia A. Showalter, Andrew Sue, Tony R. Zamro, Tiffany L. Dunbar, Kyle E. Malter, and NJ Shikuma# (In Press). Draft Genome Sequences of Ten Bacteria from the Marine Pseudoalteromonas Group. Microbiology Resource Announcements.
This is an NSF-funded publication promoting undergraduate engagement in discovery-based research.
23 undergraduate students are substantial contributors and co-authors of this work.
AT Alker, N Delherbe, T Purdy, B Moore, NJ Shikuma (2020). Genetic examination of the marine bacterium Pseudoalteromonas luteoviolacea and effects of its metamorphosis-inducing factors. Environmental Microbiology. https://doi.org/10.1111/1462-2920.15211
We uncover a hidden complexity of interactions between a single bacterial species, the factors it produces and two species of animal larvae.
Maria I. Rojas*, Giselle S. Cavalcanti*, Katelyn McNair, Sean Benler, Amanda T. Alker, Ana G. Cobián-Güemes, Melissa Giluso, Kyle Levi, Forest Rohwer, Barbara Bailey, Sinem Beyhan, Robert A. Edwards, Nicholas J. Shikuma (2020). A Distinct Contractile Injection System Gene Cluster Found in a Majority of Healthy Adult Human Microbiomes. mSystems 5:e00648-20. https://doi.org/10.1128/MSYSTEMS.00648-20
We discovered a yet undescribed Injection System genecluster in the microbiomes of nearly all adult humans.
CEricson*, FEisenstein*, J Medeiros, K Malter, G Cavalcanti, RW Zeller, DK Newman, MPilhofer# andNJShikuma# (2019). A Contractile Injection System Stimulates Tubeworm Metamorphosis by Translocating a Proteinaceous Effector. eLife 8:e46845.https://doi.org/10.7554/eLife.46845.
I Rocchi*, C Ericson*, KE Malter*, S Zargar, F Eisenstein, M Pilhofer, S Beyhan# and NJ Shikuma# (2019). A Bacterial Phage Tail-like Structure Kills Eukaryotic Cells by Injecting a Nuclease Effector. Cell Reports 28(2), 295-301.https://doi.org/10.1016/j.celrep.2019.06.019.
NJ Shikuma, JCN Fong and FH Yildiz (2012) Cellular levels and binding of c-di-GMP control subcellular localization and activity of the Vibrio cholerae transcriptional regulator VpsT. PLoS Pathogens 8(5):e1002719.
PV Krasteva, JCN Fong, NJ Shikuma, S Beyhan, MVAS Navarro, FH Yildiz and H Sondermann (2010)Vibrio cholerae VpsT regulates matrix production and motility by directly sensing cyclic di-GMP. Science 327:866-868.
NJ Shikuma and FH Yildiz (2009) Identification and characterization of OscR, a transcriptional regulator involved in osmolarity adaptation in Vibrio cholerae. Journal of Bacteriology191:4082-4096.